MMF 500mg Tablet

Uses of MMF 500mg Tablet

• To prevent rejection of a kidney, liver, or heart transplant.

How does MMF 500mg Tablet work?

MMF 500mg Tablet 10's contains Mycophenolate Mofetil, classified as an 'immunosuppressant'. It prevents organ transplant rejection by dampening the immune system's response. It does so by restraining the activity of white blood cells, which drive immune reactions. Unlike steroids with enduring side effects, MMF 500mg Tablet is a preferable option.

Side Effects of MMF 500mg Tablet

• Diarrhea
• Vomiting
• Infections
• Low white blood cell (WBC) count
• Red blood cell (RBC) count

Quick Suggestions:

• Your doctor has prescribed Mycophenolate Mofetil to stop your body from rejecting a transplanted organ (e.g. kidney, heart, or liver).
• It may take 6 to 12 weeks for Mycophenolate mofetil to start working. Keep taking it as prescribed.
• Take it with food to minimize possible side effects like nausea and stomach pain.
• It makes you more susceptible to getting infections. Avoid contact with people who have an infection. Consult your doctor immediately if you develop a sore throat, high temperature, or any other signs of infection.
• It may cause birth defects so birth control is required in females with reproductive potential.
• Protect yourself from direct sunlight by wearing protective clothing and applying sunscreen with a high sun protection factor (SPF).
• Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, or fever.

Indication of MMF 500mg Tablet

Mycophenolate Mofetil acts as an immunosuppressant by inhibiting inosine monophosphate dehydrogenase (IMPDH), a key enzyme in guanosine nucleotide synthesis. This disruption in the synthesis of DNA components hampers the proliferation of lymphocytes, exerting cytostatic effects. Furthermore, this medication curbs acute rejection of transplanted kidneys and hearts and reduces antibody generation.

Pharmacology

Mycophenolic acid operates by inhibiting inosine monophosphate dehydrogenase, an enzyme essential for purine synthesis in human lymphocytes. This action leads to reversible hindrance of purine production, effectively curbing the proliferation of both T- and B- lymphocytes.

Dosage & Administration of MMF 500mg Tablet

Adult Dosage:

• Prophylaxis of acute renal graft rejection (using Mycophenolate Mofetil - MMF): Take 1 g twice daily, starting within 72 hours of transplantation. The maximum dosage is 2 g per day.
• Prophylaxis of cardiac graft rejection, Liver Transplant: Take Mycophenolate Mofetil (MMF) at a dose of 1.5 g twice daily, starting within 5 days after transplantation.

Child Dosage:

• Children below 3 months: Safety and efficacy not established.
• Children above 3 months: For prophylaxis of organ rejection in patients receiving allogeneic renal transplants, use Mycophenolate Mofetil (MMF) as follows:
  • MMF (suspension): 600 mg/m² orally every 12 hours, not exceeding 2 g/day
  • MMF capsules/tablets: Depending on body surface area (BSA)
    • BSA 1.25-1.5 m²: Take a 750 mg capsule every 12 hours
    • BSA >1.5 m²: Take a 1 g capsule/tablet every 12 hours

Renal Impairment:

• MMF in severe renal impairment (GFR <25 mL/min/1.73 m²): Do not exceed 1 g every 12 hours.
• No dosage adjustment is needed in renal transplant patients with delayed graft function post-operatively.

Geriatric Population: 

Elderly individuals may be more susceptible to adverse events, including infections (such as cytomegalovirus tissue invasive disease), gastrointestinal hemorrhage, and pulmonary edema, compared to younger individuals.

Administration:

• Take the drug on an empty stomach, 1 hour before or 2 hours after meals.
• Once the dosage is stable, MMF can be taken with food after a kidney transplant.
• Take MMF 500mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the tablet.
• Your dosage will depend on the type of transplant received. Do not stop the medicine suddenly without consulting your doctor.

Overdose: 

• In case of excessive consumption of this medication, promptly contact your doctor or seek medical assistance at the nearest hospital.

Missed Dose:

• If you have unintentionally skipped a dose, take it as soon as you recall. However, if the next dose is approaching, skip the missed dose and adhere to the regular dosing timetable.

Interaction

Elevated plasma concentrations occur when combined with aciclovir, valaciclovir, ganciclovir, and valganciclovir. Absorption is diminished when co-administered with colestyramine, magnesium- and aluminum hydroxide-containing products, sevelamer, and other calcium-free phosphate binders. Plasma levels decrease with ciclosporin, metronidazole, quinolones, and rifamycins. Progestin plasma levels and oral contraceptive efficacy may be lowered. Plasma levels rise in conjunction with probenecid. The effectiveness of live vaccines may be compromised.

Contraindications

Avoid during pregnancy and lactation. Contraindicated in individuals with rare hereditary deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), including conditions like Kelley-Seegmiller or Lesch-Nyhan syndrome.

Pregnancy & Lactation

Mycophenolate Mofetil is contraindicated in pregnancy and during breastfeeding. The safe use of Mycophenolate Mofetil during labor and delivery has not been established.

Precautions & Warnings

Mycophenolic Mofetil tablets warrant caution due to the following reasons:

• Increased Risk of Viral Infections: Mycophenolic acid can raise the risk of new or reactivated viral infections, including latent hepatitis B or C reactivation, and infections caused by polyomaviruses.
• Blood Dyscrasias: This medication can lead to blood-related disorders, including pure red cell aplasia (PRCA).
• Serious GI Tract Complications: Mycophenolic acid use has been associated with severe gastrointestinal issues such as bleeding, perforations, and ulcers.
• Elevated Lymphoma Risk: There is a potentially heightened risk of developing lymphomas and other malignancies, particularly of the skin, when taking Mycophenolic acid.
• Avoidance of Live Vaccines: The use of live vaccines should be abstained from while undergoing treatment with Mycophenolic acid.
• Blood Donation: Patients taking Mycophenolic acid should refrain from donating blood during their therapy.

Storage Conditions

Store at a temperature below 30º C in a cool and dry place. Keep it out of the reach of children and pets.